Longevidad al Día
Las investigaciones más relevantes sobre longevidad, biohacking y medicina regenerativa — directamente de las mejores fuentes mundiales. En español, sin filtros de marketing.
Última actualización: 27 de marzo a las 12:15
RNASEK Overexpression to Remove Circular RNAs Slows Aging in Nematodes
In recent years, researchers have noted that circular RNAs accumulate in cells in old age. It has been unclear as to whether this is only a marker of dysfunction or a change that in and of itself causes further downstream issues. The fastest way to obtain an answer to this sort o
More Remaining Active Thymus Tissue Correlates with a Lower Mortality Risk
The thymus, a small organ near the heart, is important to the function of the adaptive immune system. Thymocytes migrate from bone marrow to the thymus where they mature into T cells. The thymus atrophies with age, and the loss of active thymic tissue reduces the pace at which ne
Towards More Informative Epigenetic Clocks
Aging clocks are produced from machine learning strategies applied to databases of biological data, typically omics data of various sorts, obtained from people of various ages. Patterns that change with age can be identified and an algorithm defined to take any other person's dat
CREB as an Important Player in the Decline of Immune System Control of Gut Microbiome Composition
The gut microbiome changes in composition with age in ways that harm tissue function and provoke chronic inflammation. Among the potential causes of this shift in composition is the age-related dysfunction of the immune system, allowing growth in microbial populations that should
An Aging Clock Built from Sleep Electroencephalography Data
Quality of sleep tends to decline with age for reasons both physical and neurological; sleep apnea is a concern for many older people. A broad body of literature connects sleep issues with risk of neurodegenerative conditions. Thus researchers can plausibly expect to take sleep a
Aging Impairs Activation of Muscle Stem Cells, with MG53 as a Potential Target for Therapies
Researchers have identified many contributing issues leading to the characteristic loss of muscle mass and strength that takes place with age. Arguably the central problems are (a) the disruptions of cell behavior caused by chronic inflammation, (b) damage to neuromuscular juncti
Cellular Senescence as a Contributing Cause of Muscle Aging
It has been fifteen years since the first compelling demonstration of clearance of senescent cells in mice. That study paved the way for the transformation of the research community into one convinced of the relevance of cellular senescence to degenerative aging. It also helped t
A Broad Categorization of Issues Leading to Immune Aging and Potential Strategies for Treatment
There is a reasonable consensus in the research community on the broad categories of issue that lead to and are associated with the aging of the immune system. One can start by dividing immune aging into immunosenescence, a loss of capacity, versus inflammaging, a continual state
#385 – AMA #82: Applying the tools of longevity in the real world: disease prevention, DEXA scans, artificial sweeteners, injury recovery, stability training, habit formation, protein intake and mTOR activation, and more
“ Everything we're doing is simultaneously geared towards reducing the risk of chronic disease but also improving healthspan ." —Peter Attia The post #385 – AMA #82: Applying the tools of longevity in the real world: disease prevention, DEXA scans, artificial sweeteners, injury r
When sophisticated models meet questionable premises
Mendelian randomization is a powerful tool—but not when you’re asking genes to answer the wrong question The post When sophisticated models meet questionable premises appeared first on Peter Attia .
#384 – Special episode — Obicetrapib: The CETP inhibitor with cardiovascular benefits and potential Alzheimer’s prevention
" It's hard for me to mask my personal optimism around this. I love the biological plausibility of this, and I think that obicetrapib has done something that it's four predecessors has failed to do ." —Peter Attia The post #384 – Special episode — Obicetrapib: The CETP inhibitor
An intriguing case of “exceptional resilience” against dementia
A 75-year-old man free of dementia despite a dominant Alzheimer’s mutation — and a possible hint for the rest of us The post An intriguing case of “exceptional resilience” against dementia appeared first on Peter Attia .
#383 ‒ AMA #81: Biological aging tests, longevity training, emerging therapies, GLP-1 RAs, sun exposure, and more
" If there was anything wrong with seed oils in modest quantities (again beyond the caloric effects of any oil), I'm still waiting for someone to present a convincing case for that .” —Peter Attia The post #383 ‒ AMA #81: Biological aging tests, longevity training, emerging thera
A failed endpoint is not a failed technology
GRAIL’s landmark cancer screening trial missed its composite endpoint, but a closer look at what was reported—and what wasn’t—suggests the verdict is far from settled. The post A failed endpoint is not a failed technology appeared first on Peter Attia .
#382 ‒ AMA #80: Longevity optimization through strength benchmarks, VO₂ max targets, nutrition principles, brain health, supplements, GLP-1 RAs, wearables, and more
" There doesn't appear to be an intervention that is more protective of the brain than exercise .” —Peter Attia The post #382 ‒ AMA #80: Longevity optimization through strength benchmarks, VO₂ max targets, nutrition principles, brain health, supplements, GLP-1 RAs, wearables, and
Does lowering cholesterol harm the brain?
A large genetic study suggests lifelong reductions in atherogenic lipoproteins are associated with lower—not higher—dementia risk. The post Does lowering cholesterol harm the brain? appeared first on Peter Attia .
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