Griffonia simplicifolia 99% extract canon · standard capsules · sublingual rare fast onset.
Solaray/Now/Nature's Way 6-9% natural 5-HTP
Best for
Ideal use: depression · fibromyalgia · migraine · insomnia · canon natural RCTs.
Advantages
Form used in canon RCTs (Shaw, Caruso, Maissen). African legume seed extract (Ghana, Côte d'Ivoire). HPLC standardization 99% 5-HTP purity. Stable capsules.
Disadvantages
Expensive vs synthetic (~€15-25/month 200 mg/d). Griffonia traditional African medicine history.
Commercial capsule form controlled dose
Best for
Ideal use: fine dose adjustment · starting low doses · validate brand.
Advantages
Affordable (~€10-15/month). Controlled dose · fine adjustment 100 mg increments. Premium generic brands (Now Foods, Solgar).
Disadvantages
Verify Griffonia origin vs synthetic. Some brands lower purity.
Intestinal release · reduces nausea
Best for
Ideal use: patients with GI intolerance dyspepsia to standard 5-HTP.
Advantages
Enteric coating reduces nausea/dyspepsia (common GI effect at start). Duodenum release preserves 5-HTP.
Disadvantages
Premium price · few brands. Limited NSF/USP verification.
Ideal use: depression · fibromyalgia · migraine · insomnia · canon natural RCTs.
Ideal use: fine dose adjustment · starting low doses · validate brand.
Ideal use: patients with GI intolerance dyspepsia to standard 5-HTP.
Griffonia simplicifolia 99% extract canon · standard capsules · sublingual rare fast onset.