NAD+ IV vs Vitamin C IV vs Glutathione IV: The Definitive Guide

Advantages

• Activates sirtuins (SIRT1-7): longevity enzymes
• DNA repair and reduction of senescent cells
• Notable cognitive improvement and mental clarity
• Only route to rapidly restore intracellular NAD+
• Backed by Harvard research (David Sinclair)

Disadvantages

• The most expensive of the three options
• Slow infusion: 1.5–4 hours
• May cause nausea if administered too quickly
• Requires a clinic with specific expertise

Advantages

• The most studied: thousands of published clinical trials
• Bioavailability 6–10x superior to oral
• Potent immunostimulant effect (10–75 g IV)
• More affordable than NAD+
• Session of 30–90 min

Disadvantages

• Does not act on sirtuins or telomeres directly
• Requires prior G6PD test for high doses
• Contraindicated in severe renal insufficiency
• Lesser effect on cognition vs NAD+

Advantages

• The body's principal intracellular antioxidant
• Potent hepatic detoxification effect
• Visible skin improvement (luminosity, pigmentation)
• Neuroprotective: low levels associated with Parkinson's disease
• Quick session (15–30 min IV push)

Disadvantages

• Bioavailability questioned when administered IV alone (rapid degradation)
• Best combined with Vitamin C IV to enhance absorption
• Less direct evidence in longevity vs NAD+
• Effect more aesthetic than deeply therapeutic