Canonical combo
NAD+ IV Therapy + Cryotherapy
Documented synergy between NAD+ IV Therapy and Cryotherapy. Canonical combination in literature · see protocol and evidence.
View comparison →NAD+ IV Therapy · Minimally invasive (IV)
Report · May 2026
Minimally invasive (IV)High evidence
Library · Treatment
NAD+ IV Therapy in Spain: Prices, Scientific Evidence & Top Clinics
Restore cellular energy and slow the ageing process
Definition and how it works: NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme present in every cell, vital for energy production (ATP), DNA repair, and sirtuin regulation. NAD+ IV therapy delivers this coenzyme directly into the bloodstream, achieving plasma levels impossible to reach with oral supplementation. NAD+ levels decline by up to 50% between the ages of 40 and 60 — a process directly linked to ageing.
Duration
initial protocol: 4–6 infusions
Frequency
1–2 infusions/week
Cost in Spain
€180–400 per infusion
Evidence
4+
Before you read
Key terms
Autophagy→The cellular recycling system that activates longevity pathwaysBiological Age→The true age of your cells, independent of your date of birthBiohacking→Systematic optimisation of the body using science and technologyPro-inflammatory Cytokines→The proteins that control inflammation — and become dysregulated with ageingEpigenetics→How the environment modifies gene expression without changing the DNAGlutathione→The body's master antioxidant
What is NAD+ IV Therapy?
NAD+ (nicotinamide adenine dinucleotide) is an essential coenzyme present in every cell, vital for energy production (ATP), DNA repair, and sirtuin regulation. NAD+ IV therapy delivers this coenzyme directly into the bloodstream, achieving plasma levels impossible to reach with oral supplementation. NAD+ levels decline by up to 50% between the ages of 40 and 60 — a process directly linked to ageing.
Origin and history
NAD+ was discovered by Harden and Young in 1906. Its central role in longevity was revealed by research at MIT and Harvard between 2013 and 2020, sparking a global boom in longevity clinics.
NAD+ IV Therapy protocol step by step
1. Baseline blood work Plasma NAD+ measurement, liver and kidney function tests before starting.
2. Venous access Peripheral IV cannulation. Drip started at a low rate (10 mg/min).
3. Progressive infusion Dose of 250–1,000 mg over 1.5–4 hours. Rate adjusted based on tolerance.
4. Monitoring Heart rate, blood pressure and symptom checks. Medical staff present throughout.
5. Post-infusion Oral hydration. Energy and cognitive effects logged over the following 24–48 hours.
Benefits of NAD+ IV Therapy
- Noticeable increase in energy and mental clarity
- Activation of sirtuins (longevity enzymes SIRT1–SIRT7)
- Accelerated DNA repair and reduced oxidative damage
- Improved cognitive function and neuroprotection
- Support for detoxification and craving reduction
- Enhanced insulin sensitivity and metabolic function
Who is NAD+ IV Therapy for?
- 1People experiencing chronic fatigue or cognitive decline
- 2Executives and biohackers seeking peak performance
- 3Individuals over 40 interested in anti-ageing
- 4High-performance athletes
- 5People in addiction recovery (under medical supervision)
Precautions and contraindications for NAD+ IV Therapy
- Active cancer (requires prior medical evaluation)
- Severe renal or hepatic insufficiency
- Known hypersensitivity to niacinamide
- Pregnancy or breastfeeding
Reference equipment for NAD+ IV Therapy
| Equipment | Brand / Model | Technical detail |
|---|---|---|
| IV infusion pump | B. Braun Infusomat / Baxter | Precise drip rate control in ml/h to minimise side effects. |
| Pharmaceutical-grade NAD+ | Tru Niagen / Jinfiniti / Compounding pharmacy | Pharmaceutical-grade NAD+ in saline solution. Purity control >99%. |
Clinics on LongevityMap declare their exact equipment for objective scoring.
Editorial note
Restore cellular energy and slow the ageing process
How much does NAD+ IV Therapy cost in Spain?
€180–400 per infusion
1–2 infusions/week (initial protocol: 4–6 infusions)
Prices vary by clinic, equipment and practitioner experience. LongevityMap compares price and quality so you always make the best decision.
Top clinics in Spain for NAD+ IV Therapy
Where to get NAD+ IV Therapy in Spain?
Treatments that combine with NAD+ IV Therapy
Canonical combo
NAD+ + IV Therapy IV Therapy
Documented synergy between NAD+ IV Therapy and IV Therapy. Canonical combination in literature · see protocol and evidence.
View comparison →Canonical combo
NAD+ IV Therapy + Hyperbaric Chamber
Documented synergy between NAD+ IV Therapy and Hyperbaric Chamber. Canonical combination in literature · see protocol and evidence.
View comparison →Testimonials
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We are collecting signed consents under GDPR Art. 9.2.a. First verified testimonials will appear once the first real clinics are onboarded (Q4 2026).
The science behind NAD+ IV Therapy
Research at Harvard University (Dr. David Sinclair's lab) shows that restoring NAD+ levels activates sirtuins and the mTOR pathway, reversing epigenetic ageing markers in animal models. Clinical trials in humans (Washington University, 2018) confirm improvements in insulin resistance and muscle function with NAD+ precursor infusions. IV bioavailability is 6–10 times higher than oral.
- NAD+ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidenceAgeing Research Reviews · 2026
PRISMA systematic review 2026 (113 studies, 33 in humans): oral NAD+ precursors (NR, NMN) show biochemical engagement and good tolerance; however, clinical efficacy for anti-aging remains inconclusive and no controlled trials of intravenous NAD+ for anti-aging indications exist.
- Safety and efficacy of individualised exercise and NAD+ precursor supplementation in patients with Friedreich's ataxia in the USA: a single-centre, 2 × 2 factorial, randomised controlled trialThe Lancet Neurology · 2026
Phase 2 RCT Lancet Neurology 2026 (n=66, Friedreich's ataxia): 12 weeks of nicotinamide riboside + individualised exercise significantly improved cardiopulmonary fitness (peak VO2) vs control. Combination was safe and well tolerated.
- Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exerciseJournal of the International Society of Sports Nutrition · 2026
2026 crossover RCT (n=11 untrained men): oral NMN (1,200 mg/d × 7 d) suppressed muscle inflammatory signaling (TNF-α, IL-10 mRNA) after blood-flow-restriction exercise, though it also attenuated mitochondrial replenishment.
- Double-Pronged NAD Preservation: Delaying Cellular Senescence and Initiating Musculoskeletal RegenerationAging Cell · 2026
Aging Cell 2026 (mouse model): NMN + apigenin formulation increased NAD+ reserves, alleviated cellular senescence and promoted cartilage, bone and muscle regeneration in aged mice. Preclinical evidence with translational potential.
Last bibliographic review: 2026-03-28.
Frequently asked questions about NAD+ IV Therapy
Does the infusion hurt or cause side effects?
The infusion may cause a sensation of warmth, chest tightness, or mild nausea if administered too quickly. At quality clinics the drip rate is individually adjusted to minimise these effects. They usually resolve by slowing the rate.
How long does a NAD+ IV session take?
Between 1.5 and 4 hours depending on the dose (typically 250–1,000 mg). Some clinics offer accelerated high-dose infusions with continuous medical supervision.
What's the difference between NAD+ IV and NMN/NR supplements?
Oral NMN and NR supplements are precursors the body converts into NAD+, with limited conversion efficiency. NAD+ IV delivers the coenzyme directly to the bloodstream with maximum bioavailability.
People also ask
Does the infusion hurt or cause side effects?→How long does a NAD+ IV session take?→What's the difference between NAD+ IV and NMN/NR supplements?→NAD+ IV vs Vitamin C IV vs Glutathione IV: The Definitive Guide→Hyperbaric Chamber vs Ozone Therapy: Two Oxygen Therapies Compared→NAD+ IV vs Oral NMN: Which Is More Effective?→Vitamin C IV vs Glutathione IV: Elite Antioxidants Compared→
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