Canonical combo
PRP – Platelet-Rich Plasma + Exosome Therapy
Documented synergy between PRP – Platelet-Rich Plasma and Exosome Therapy. Canonical combination in literature · see protocol and evidence.
View comparison →PRP (Platelet-Rich Plasma) · Minimally invasive
Report · May 2026
Minimally invasiveHigh evidence
Library · Treatment
PRP in Spain: Platelet-Rich Plasma Guide, Prices & Verified Clinics
Natural regeneration powered by your own blood
Definition and how it works: PRP (Platelet-Rich Plasma) is an autologous regenerative therapy that uses the patient's own blood. A small blood sample is drawn, centrifuged to concentrate the platelets (5–10 times the normal concentration) and the resulting plasma — rich in growth factors — is reinjected into the target area. Growth factors (PDGF, TGF-β, VEGF, EGF) stimulate cellular regeneration and new tissue formation.
Duration
4 weeks apart
Frequency
3 sessions
Cost in Spain
€150–350 per session
Evidence
4+
Before you read
Key terms
What is PRP – Platelet-Rich Plasma?
PRP (Platelet-Rich Plasma) is an autologous regenerative therapy that uses the patient's own blood. A small blood sample is drawn, centrifuged to concentrate the platelets (5–10 times the normal concentration) and the resulting plasma — rich in growth factors — is reinjected into the target area. Growth factors (PDGF, TGF-β, VEGF, EGF) stimulate cellular regeneration and new tissue formation.
Origin and history
PRP was developed in haematology in the 1970s for transfusions. Its use in oral surgery began in the 1990s and expanded to sports and aesthetics from 2006 onwards, after several elite footballers popularised it for treating serious injuries.
PRP – Platelet-Rich Plasma protocol step by step
1. Blood draw 15–60 ml of peripheral venous blood drawn (identical to a standard blood test).
2. Centrifugation Centrifuged at 2,500–3,000 rpm for 10–15 min to separate platelet-rich plasma.
3. Activation (optional) Activation with calcium chloride or thrombin to release growth factors.
4. Injection Guided application (ultrasound/fluoroscopy) to target area under local anaesthesia.
5. Post-treatment Relative rest for 24–48 hours. Avoid NSAIDs. Follow-up at 4–6 weeks.
Benefits of PRP – Platelet-Rich Plasma
- Soft tissue and cartilage regeneration
- Non-surgical facial and hair rejuvenation
- Reduction of chronic joint pain (knee, shoulder, hip)
- Accelerated healing of sports injuries
- Stimulation of hair growth in androgenic alopecia
- Improved skin texture and radiance
Who is PRP – Platelet-Rich Plasma for?
- 1People with osteoarthritis or chronic tendon injuries
- 2Athletes with musculotendinous injuries
- 3People with early or moderate androgenic alopecia
- 4Those seeking natural facial rejuvenation
- 5Post-surgical recovery patients
Precautions and contraindications for PRP – Platelet-Rich Plasma
- Thrombocytopenia or coagulation disorders
- Active infection at the injection site
- Anticoagulant therapy (requires medical evaluation)
- Active cancer in the treated area
Reference equipment for PRP – Platelet-Rich Plasma
| Equipment | Brand / Model | Technical detail |
|---|---|---|
| Double-spin medical centrifuge | Harvest SmartPreP / Arthrex ACP | 5–10× platelet concentration. CE/FDA certified for PRP. |
| Ultrasound guidance | GE Logiq / Mindray | Real-time ultrasound guidance for articular and tendon injections. |
Clinics on LongevityMap declare their exact equipment for objective scoring.
Editorial note
Natural regeneration powered by your own blood
How much does PRP – Platelet-Rich Plasma cost in Spain?
€150–350 per session
3 sessions (4 weeks apart); annual maintenance
Prices vary by clinic, equipment and practitioner experience. LongevityMap compares price and quality so you always make the best decision.
Top clinics in Spain for PRP – Platelet-Rich Plasma
Where to get PRP – Platelet-Rich Plasma in Spain?
Treatments that combine with PRP – Platelet-Rich Plasma
Canonical combo
PRP – Platelet-Rich Plasma + Stem Cell Therapy
Documented synergy between PRP – Platelet-Rich Plasma and Stem Cell Therapy. Canonical combination in literature · see protocol and evidence.
View comparison →Canonical combo
PRP – Platelet-Rich Plasma + HIFU & Radiofrequency
Documented synergy between PRP – Platelet-Rich Plasma and HIFU & Radiofrequency. Canonical combination in literature · see protocol and evidence.
View comparison →Testimonials
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The science behind PRP – Platelet-Rich Plasma
Over 10,000 published studies support PRP. Meta-analyses in the American Journal of Sports Medicine confirm its superiority over hyaluronic acid for knee osteoarthritis at 12 months. In dermatology, controlled trials show 35–40% increases in hair density after 3 sessions. Platelet concentration and the activation protocol are critical quality factors.
- Platelet-Rich Plasma Is More Effective Than Hyaluronic Acid Injections for Osteoarthritis of the Knee: A Meta-analysis Based on Randomized, Double-Blinded, Controlled Clinical TrialsArthroscopy · 2025
Meta-analysis 15 double-blind RCTs (n=1,632 knee OA patients): intra-articular PRP significantly superior to hyaluronic acid in pain reduction (WOMAC, VAS) at 12 months, reaching the minimal clinically important difference.
- Comparative Efficacy and Safety of Platelet Rich Plasma (PRP) versus Topical Minoxidil for Androgenetic Alopecia: A Systematic Review and Meta-analysisAesthetic Plastic Surgery · 2026
SR/MA 9 RCTs (n=451, androgenetic alopecia): PRP showed no clear advantage over 5% minoxidil in hair density, but higher patient satisfaction (OR 2.77) and better negative pull-test results (82.75% vs 52.94%).
- Efficacy of platelet-rich plasma as a conservative and surgical adjuvant treatment for chronic midportion Achilles tendinopathy: a systematic review and meta-analysisThe Physician and Sportsmedicine · 2026
SR/MA 8 studies (n=507, chronic Achilles tendinopathy): PRP provides only short-term functional improvement (VISA-A); no significant long-term benefit nor as a surgical adjunct. Standardised protocols needed.
- Effects of percutaneous platelet-rich plasma injection on return-to-play after acute hamstring muscle injury: a systematic review and meta-analysisBritish Journal of Sports Medicine · 2026
SR/MA 6 RCTs (n=277, acute hamstring injury): percutaneous PRP reduced return-to-play time by 8.6 days (21.4 vs 30.0; p=0.045), especially when image-guided. No differences in re-injury or adverse events.
Last bibliographic review: 2026-03-28.
Frequently asked questions about PRP – Platelet-Rich Plasma
Is PRP painful?
Topical or local anaesthesia is applied before injections. The blood draw is identical to a standard blood test. Post-procedure discomfort is mild and lasts 1–2 days.
When will I see results from hair PRP?
Initial results (reduced hair loss) are visible at 2–3 months. Visible new hair growth is typically observed between 4 and 6 months after starting the protocol.
Is there any risk of rejection with PRP?
No, because the patient's own blood is used. The risk of allergic reaction or rejection is virtually nil, making PRP one of the safest regenerative therapies available.
People also ask
Is PRP painful?→When will I see results from hair PRP?→Is there any risk of rejection with PRP?→PRP vs Exosomes vs Stem Cells: Which Is Best for Regeneration?→HIFU vs Surgical Facelift: Is Surgery Worth It?→PRP vs Hyaluronic Acid: Which Regenerates Skin and Joints Better?→Stem Cells vs PRP for Hair Loss: Complete Comparison→
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