Longevity Daily
The most relevant research on longevity, biohacking, and regenerative medicine — straight from the world’s best sources. No marketing filters.
Assessing the Merits of Trained Immunity via BCG Vaccination to Treat or Prevent Alzheimer's Disease
Vaccinations can produce a lasting effect known as trained immunity, altering the behavior of the innate immune system and resulting in both a reduction in the chronic inflammation of aging and a more effective immune response to unrelated infectious agents. Arguably the largest
Senescent Cells Contribute to Damage and Dysfunction Following a Heart Attack
Senescent cells are involved in tissue regeneration. Cells enter a senescent state following injury, and in the usual course of events assist in the intricate coordination between immune cells, stem cells, and other cell types that is required to regrow tissue. These senescent ce
Senolytic Treatment with Dasatinib and Quercetin Rejuvenates the Aging Kidney in Mice
There is a large body of evidence in animal studies to show that treatment with dasatinib and quercetin clears a fraction of the lingering senescent cells present in tissues throughout the body to restore more youthful function to many different organs and systems. Today's open a
Known Ways in Which the Gut Microbiome Influences Aging of Muscle and Brain
Animal studies suggest that the composition of the gut microbiome is at least as important as diet and exercise when it comes to influencing the pace and progression of aging. Both diet and exercise influence the gut microbiome as well - nothing in the body acts in isolation. The
Vascular Organoids to Regrow Microvessels in Heart Tissue
Researchers here describe an approach to encouraging regrowth of small vessels in heart tissue, involving transplantation of organoids composed of the various cell types needed to form new vessels. Like other cell therapy strategies for an injured or aged heart, delivery involves
SIRT6 Variants Found in Centenarians Produce a Lower Burden of Cellular Senescence
The point of studying the biochemistry of very long-lived humans is to try to better understand which of the many underlying mechanisms of damage and dysfunction that drive degenerative aging are the most important and thus should be prioritized for the development of therapies.
Arc is Involved in Transmission of Tau Between Neurons in Alzheimer's Disease
The more severe later stages of Alzheimer's disease are characterized by altered forms of tau protein aggregating inside neurons to cause dysfunction, inflammation, and cell death. Researchers here show that tau can spread between neurons via extracellular vesicles, and identify
Imidazole Propionate Generated by Gut Microbes Accelerates Neurodegeneration
The gut microbiome generates a vast range of metabolites, some beneficial or even necessary to health, and some actively harmful, provoking chronic inflammation or other dysfunction. With age the balance of microbial populations making up the gut microbiome changes for the worse.
Building strength and muscle mass: how to optimize training, nutrition, and more for longevity (AMA #71 rebroadcast)
“The more you move, the more you’re alive. The less you move, the less you’re alive.” —Peter Attia The post Building strength and muscle mass: how to optimize training, nutrition, and more for longevity (AMA #71 rebroadcast) appeared first on Peter Attia MD .
Metformin and cancer: active surveillance needed
Metformin failed in prostate cancer and many others—but exceptions remind us to think with precision about interventions The post Metformin and cancer: active surveillance needed appeared first on Peter Attia MD .
Muscle preservation during GLP-1 treatment: when protocol beats pharmacology
Muscle loss with GLP-1 is not inevitable. Peter Attia shows that with proper protein dosing and structured resistance training, lean mass loss becomes negligible.
High HDL cholesterol isn't the cardiovascular shield we thought it was
Elevated HDL cholesterol levels don't automatically protect heart health as conventional wisdom suggests. Peter Attia unpacks why this metric demands far more nuanced clinical interpretation.
Lung cancer screening in never-smokers: why the evidence supports this choice
Medical guidelines don't endorse it, yet the scientific evidence suggests lung cancer screening in never-smokers is a rational, data-driven decision worth considering.
Endometriosis and adenomyosis: early diagnosis prevents 40% of disease burden
Detecting endometriosis in adolescents and young women prevents up to 40% of future disease progression. World-leading specialist Renato Tomioka explains how early diagnosis transforms reproductive outcomes and reproductive longevity.
Do AI models reason like clinicians?
Frontier large language models fail where it matters most: in the clinical reasoning that protects patient safety. A landmark analysis reveals the critical gap.
Breast cancer screening: closing the gap between science and clinical practice
The evidence on breast cancer screening is solid, yet a critical gap persists: the divide between what medicine knows and what women actually do. Peter Attia exposes how to bridge that distance.
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