Longevity Daily
The most relevant research on longevity, biohacking, and regenerative medicine — straight from the world’s best sources. No marketing filters.
Exploring How Cellular Senescence Spreads in the Aging Brain
Senescent cells accumulate with age throughout the body, either in response to forms of damage and stress or on reaching the Hayflick limit on replication. A senescent cell ceases to replicate, grows in size, and secretes a potent mix of pro-growth, pro-inflammatory signals. In y
Reviewing the Contribution of Mitochondrial Supercomplexes to Aging and Longevity
The various mitochondrial protein complexes are the building blocks of the electron transport chain, the complicated mechanism inside mitochondria that generates adenosine triphosphate (ATP), the chemical energy store molecule used to power cell activities. Nothing in a cell is s
Reduced INDY Expression in Flies Causes Gut Dysbiosis
Old fruit flies generally die from intestinal dysfunction; intestinal aging is the most important aspect of aging in this species. INDY is a longevity associated gene that has been shown to have important effects on intestinal health in flies. Upregulation of INDY expression exte
#405 ‒ AMA #88: Metabolic liver health: how to assess risk, catch dysfunction early, and prevent or reverse liver disease
“The disease can be reversible and that's why we make so much hay about intervening early. We address the metabolic drivers, and we see that steatosis and fibrosis in the earlier stages can regress, especially the earlier the fibrosis is caught.”‒ Peter Attia The post #405 ‒ AMA
Fight Aging! Newsletter, August 24th 2026
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the n
Gum recession: the silent deterioration your own habits may be accelerating
Gum recession is frequent and often invisible until irreversible damage occurs. The paradox: the very gestures you believe protect your teeth may be accelerating their decline.
TIMP2 reverses inflammatory aging of brain microglia
A youth-associated protein restores immune cell function in the aging brain. Treated aged mice show reduced microglial inflammation and enhanced clearance of neurological debris.
The NLRP3 inflammasome: the hidden driver of macular degeneration
Chronic low-grade retinal inflammation activates a molecular switch—the NLRP3 inflammasome—that accelerates central vision loss. Researchers reveal how selective blocking of this pathway could halt macular degeneration without disarming necessary immune defenses.
The histological clock that measures your organs' true biological age
Scientists have created biological clocks that predict the true age of 40 human tissue types by analyzing 25,712 microscopic images. The breakthrough enables detection of accelerated aging from a single blood sample.
RANKL inhibition slows aging hallmarks in progeroid mice
A neutralizing antibody against RANKL reversed bone loss and extended lifespan in accelerated-aging mice. Treated animals also showed increased grip strength and improved endurance.
Beyond neurotransmitters: why psychiatry must restore life, not just silence symptoms
Modern psychiatry stops at reducing symptoms, but forgets to restore the complete human experience. One psychiatrist redefines mental health success beyond neurotransmitters.
Multifactorial trials: what they prove and what they don't
Trials that blend everything together reveal correlations, but hide which ingredient actually works. Peter Attia explains why this distinction matters more than it appears.
Peptides: why scientific rigor matters more than ever
Peptides are molecularly powerful, which demands greater caution, not less. Peter Attia warns against normalizing careless use of actual drugs under the guise of biohacking.
Protein restriction in modern nephrology: dogma or evidence?
The case for limiting protein to protect kidneys stems from an older era of nephrology. Contemporary medicine is now questioning whether this recommendation still holds.
NMR blood analysis: one sample reveals cardiovascular risk, inflammation, insulin resistance, and mortality
A single blood test goes far beyond cholesterol: NMR captures cardiovascular risk, inflammatory markers, insulin resistance, and mortality prediction in one scan.
Coronary calcium score of zero does not eliminate cardiovascular risk
A zero calcium score provides reassurance, but should not override clinical concern about sustained LDL-C elevation in younger adults. Structural absence of plaque does not guarantee protection against future events.
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