Enteric Na/Ca-butyrate capsule canon · tributyrin stable pro-drug alternative · fermented postbiotic niche.
DR capsule (delayed-release) releases in colon
Best for
Ideal use: IBD · leaky gut · IR · depression · DEFAULT clinical canon.
Advantages
Form used in canon Vanhoutvin/Canfora RCTs. Targeted colon release (avoids stomach/small intestine absorption). 600-1200 mg/capsule. Stable.
Disadvantages
Butyrate's signature odor (rancid butter) if capsule breaks. DO NOT chew. Medium-high cost (~€30-50/month 2 g/d).
Triglyceride 3× butyrate · stomach-stable
Best for
Ideal use: leaky gut · Na-butyrate smell intolerance · sustained release.
Advantages
Stable pro-drug · doesn't need enteric coating. Intestinal lipase releases butyrate gradually. No smell. Tributyrin = 3 butyrates per molecule (efficient per g).
Disadvantages
Fewer head-to-head studies vs Na/Ca-butyrate. Expensive (~€50-70/month). Limited availability.
Butyrate-rich dead bacterial products
Best for
Ideal use: maintenance + multi-postbiotic stack · NOT therapeutic IBD.
Advantages
Combines butyrate + other bacterial metabolites (SCFAs, exopolysaccharides). Some commercial products (e.g., Microbiome Labs MegaSporeBiotic post-fermentation).
Disadvantages
Less butyrate per capsule (~100-300 mg vs 600-1200 mg direct). More expensive per g of butyrate. Few head-to-head RCTs.
Ideal use: IBD · leaky gut · IR · depression · DEFAULT clinical canon.
Ideal use: leaky gut · Na-butyrate smell intolerance · sustained release.
Ideal use: maintenance + multi-postbiotic stack · NOT therapeutic IBD.
Enteric Na/Ca-butyrate capsule canon · tributyrin stable pro-drug alternative · fermented postbiotic niche.