Full-spectrum ≤0.2% THC entourage canon · broad-spectrum THC-free · 99% CBD isolate · Epidiolex Rx epilepsy.
CBD + CBG + CBC + cannabis terpenes + flavonoids + trace THC
Best for
Ideal use: ALL indications · clinical canon · OTC Spain default.
Advantages
Canon RCT form most studies (Russo, Shannon, Crippa). Entourage effect · CBD + minor cannabinoids + terpenes synergy superior to isolate. Spain OTC legal ≤0.2% THC.
Disadvantages
Trace THC may cause false positive workplace drug test. Intense cannabis flavor (some sensitive).
CBD + minor cannabinoids + terpenes · THC eliminated
Best for
Ideal use: WADA-tested athletes · drug-tested professionals · pregnancy/lactation (NOT recommended anyway).
Advantages
THC-free = no workplace drug test false positive. Maintains partial entourage. For professionals subject to workplace tests.
Disadvantages
Costly vs full-spectrum (additional processing). Clinical efficacy slightly lower vs full-spectrum (partial entourage lost).
Pure crystal isolated CBD · no minor cannabinoids
Best for
Ideal use: CBD cosmetics (creams/skincare) · when entourage not priority · terpene sensitivity.
Advantages
THC-free (zero). Precise controlled dose. Versatility capsules/edibles/cosmetics. Epidiolex is pure isolate.
Disadvantages
Loses entourage effect. Reduced clinical efficacy vs full-spectrum. Less pronounced Russo bell-shape curve.
Pharmaceutical isolate CBD 99.5% purity · Rx hospital
Best for
Ideal use: refractory pediatric epilepsy · under pediatric neurology.
Advantages
FDA + EMA approved 2018-2019 · Dravet + Lennox-Gastaut + TSC. Gold standard refractory pediatric epilepsy.
Disadvantages
Pediatric neurology Rx only. Expensive (~€3000/month). NO adult anxiety/pain indication.
Ideal use: ALL indications · clinical canon · OTC Spain default.
Ideal use: WADA-tested athletes · drug-tested professionals · pregnancy/lactation (NOT recommended anyway).
Ideal use: CBD cosmetics (creams/skincare) · when entourage not priority · terpene sensitivity.
Ideal use: refractory pediatric epilepsy · under pediatric neurology.
Full-spectrum ≤0.2% THC entourage canon · broad-spectrum THC-free · 99% CBD isolate · Epidiolex Rx epilepsy.