Only monohydrate has solid human evidence. Other forms are marketing without comparative RCTs.
Only form with clinical evidence
Best for
Ideal use: 99% of cases. Absolute gold standard.
Advantages
700+ human RCTs · certified Creapure® purity (AlzChem · Germany) · zero contaminants. Limited solubility compensated with time (5 min dissolve) or warmth.
Disadvantages
Some patients report GI distress in loading phase · soluble in warm water better than cold.
Premium marketing · no comparative RCTs
Best for
Ideal use: none · pure marketing investment.
Advantages
Marketing claim of higher solubility. Lower doses (3 g) for «superior» absorption (unproven).
Disadvantages
Zero head-to-head RCTs with monohydrate showing advantage. 3-5× more expensive. NOT recommended by any scientific panel.
Discredited form
Best for
Ideal use: NEVER buy under any circumstance.
Advantages
Promise of higher cellular permeability · liposoluble.
Disadvantages
Actually degrades to creatinine (inert) in stomach · LOWER muscle saturation than monohydrate (Spillane 2009). Product discredited in literature.
Ideal use: 99% of cases. Absolute gold standard.
Ideal use: none · pure marketing investment.
Ideal use: NEVER buy under any circumstance.
Only monohydrate has solid human evidence. Other forms are marketing without comparative RCTs.