40:1 ratio PCOS canon · myo alone IVF/GD/anxiety · high DCI CONTRAINDICATED PCOS (Unfer paradox).
Inofolic Combi / Wellfertil canon
Best for
Ideal use: PCOS · fertility · female metabolic syndrome.
Advantages
Physiological plasma ratio · Unfer 2024 PCOS canon. Restores ovarian MI→DCI epimerase. Best PCOS RCT evidence.
Disadvantages
Expensive · especially fertility liquid formulation (~40-60 €/month). Bulk powder cheaper.
Pure MI 99% without DCI
Best for
Ideal use: gestational diabetes, IVF, anxiety/panic (Mukai 18 g), non-PCOS general.
Advantages
Economical bulk powder (~15-22 €/month at 4 g/d). Form used in gestational diabetes + IVF + panic/anxiety high-dose RCTs. Better for non-PCOS indications.
Disadvantages
Sub-optimal PCOS if alone · physiological ratio requires complementary DCI.
DCI ≥600 mg/d without myo
Best for
Ideal use (limited): specific non-PCOS endocrinology cases. NOT in PCOS.
Advantages
Specific cases severe insulin resistance without PCOS.
Disadvantages
CONTRAINDICATED PCOS · Unfer paradox: high DCI in ovary worsens androgens. NEVER use high DCI alone in PCOS. Only under non-PCOS endocrinology.
Ideal use: PCOS · fertility · female metabolic syndrome.
Ideal use: gestational diabetes, IVF, anxiety/panic (Mukai 18 g), non-PCOS general.
Ideal use (limited): specific non-PCOS endocrinology cases. NOT in PCOS.
40:1 ratio PCOS canon · myo alone IVF/GD/anxiety · high DCI CONTRAINDICATED PCOS (Unfer paradox).