USP free-form powder canon · L-alanyl-Gln stable IV dipeptide for critical care · capsules for low doses.
Crystalline powder · canon form for oral studies
Best for
Ideal use: leaky gut · IBD · mucositis · exercise · DEFAULT oral canon.
Advantages
Form used in most oral RCTs (Mottaghi, Sayles, Pugh). Economical, flexibly dosable 5-30 g, stable as dry powder. Oral bioavailability ~70%.
Disadvantages
Neutral but slightly metallic taste. Dissolution requires warm water. Unstable in aqueous solution >24h.
Glamin / Dipeptiven · hospital IV critical care
Best for
Ideal use: intensive care · sepsis · post-major surgery · hospital only.
Advantages
Stable in aqueous solution (free Gln is unstable). Wernerman 2024 ICU RCTs use IV dipeptide. IV bioavailability ~95%.
Disadvantages
Hospital IV use only · NOT OTC available. Expensive. Requires pump.
Low-dose convenience capsules
Best for
Ideal use: low maintenance (2-5 g/d) · travel · NOT useful for therapeutic doses.
Advantages
More convenient for travel · no water/dissolution required. Controlled dose.
Disadvantages
Expensive to reach 10-30 g/d (40-60 capsules/day). Capsule fillers.
Ideal use: leaky gut · IBD · mucositis · exercise · DEFAULT oral canon.
Ideal use: intensive care · sepsis · post-major surgery · hospital only.
Ideal use: low maintenance (2-5 g/d) · travel · NOT useful for therapeutic doses.
USP free-form powder canon · L-alanyl-Gln stable IV dipeptide for critical care · capsules for low doses.