Magtein patent Magceutics canon · other forms do NOT cross BBB · triple stack complete coverage.
Magnesium L-threonate MIT patent 8% elemental Mg
Best for
Ideal use: cognitive · deep sleep · anxiety · neuropathic pain · ANY brain action.
Advantages
ONLY form with significant BBB cross. Canon RCTs Slutsky/Liu MIT 2010 + Zhang 2024. HPLC standardization. Excellent GI tolerability (no diarrhea like citrate).
Disadvantages
Expensive (~€30-50/month). High dose (1500-2000 mg) needed. Low elemental Mg (144 mg) · NOT enough alone for systemic Mg.
Brain + systemic + energy coverage
Best for
Ideal use: complete longevity stack · systemic + BBB coverage · serious health optimization.
Advantages
Optimal coverage: Magtein brain + glycinate systemic anxiety + malate muscular energy/fibromyalgia. Covers 400 mg total elemental Mg RDA.
Disadvantages
Requires 3 supplements · more complex. Higher combined cost.
Systemic Mg NO BBB cross
Best for
Ideal use: systemic Mg deficiency only · NO brain action.
Advantages
Affordable. Cover RDA 400 mg systemic Mg. Good GI tolerability.
Disadvantages
Do NOT cross BBB significantly. For brain effects (cognitive, SWS sleep) insufficient alone.
Ideal use: cognitive · deep sleep · anxiety · neuropathic pain · ANY brain action.
Ideal use: complete longevity stack · systemic + BBB coverage · serious health optimization.
Ideal use: systemic Mg deficiency only · NO brain action.
Magtein patent Magceutics canon · other forms do NOT cross BBB · triple stack complete coverage.