CNCM I-745 (Florastor/Ultra-Levura) canon · only strain with canon RCTs · other "Saccharomyces boulardii" vary in efficacy.
Institut Pasteur 1923 patented strain
Best for
Ideal use: ANY RCT clinical indication · replicate exact protocol.
Advantages
Form used in 95% of canon RCTs (McFarland, Kollaritsch, Guslandi, Szajewska). HPLC standardization + documented viability. OTC pharmaceutical product Spain (Ultra-Levura).
Disadvantages
Expensive vs generics (~€20-30/month). Biocodex (FR) patent raises price.
Brands without CNCM I-745 documented
Best for
Ideal use (limited): general maintenance · NOT specific clinical indications.
Advantages
Affordable (~€10-15/month). Some brands use related strains with some evidence.
Disadvantages
Clinical efficacy NOT equivalent · strain-specific applies to yeasts too. CFU/viability variability.
Ideal use: ANY RCT clinical indication · replicate exact protocol.
Ideal use (limited): general maintenance · NOT specific clinical indications.
CNCM I-745 (Florastor/Ultra-Levura) canon · only strain with canon RCTs · other "Saccharomyces boulardii" vary in efficacy.