Vitamin C IV vs Glutathione IV: Elite Antioxidants Compared

Advantages

• At IV doses (>10 g): plasma concentrations 100x higher than oral route
• Selective pro-oxidant in tumour cells at high doses (>25 g): evidence in integrative oncology
• Collagen synthesis: demonstrated effect on skin quality at 8 weeks
• Extensive evidence in chronic fatigue and post-viral syndrome
• Very well tolerated: excellent safety profile

Disadvantages

• Contraindicated in G6PD deficiency (may cause haemolysis)
• Incompatible with NAD+ in the same infusion (mutual oxidation)
• Long sessions: 60–120 min for doses of 25–50 g
• Additional benefit of IV vs oral debated for concentrations below 10 g

Advantages

• Principal intracellular antioxidant: regenerates oxidised vitamin C, E and uric acid
• Potent hepatic detoxification effect (conjugation of heavy metals and toxins)
• Improves skin texture and luminosity in 4–8 weeks
• Neuroprotective effect: used in Parkinson's and neurodegeneration protocols
• Reduces systemic oxidative stress measured by 8-OHdG and F2-isoprostanes

Disadvantages

• Oral bioavailability near zero: only IV, liposomal or nebulised route has real effect
• Degrades rapidly if not administered correctly (temperature, speed)
• Do not combine with Vitamin C IV in the same session: they compete in the antioxidant chain
• May lighten the skin undesirably at very high doses (controversial aesthetic use)