3 forms with radically different bioavailability · canon 2026 pro liposomal · common ascorbic for low dose · Ester-C more marketing than science.
LivOn Labs, Quicksilver, Renue · sunflower lecithin
Best for
Ideal use: pro wellness protocol, doses >1 g/d without diarrhea, immune prophylaxis, endothelium.
Advantages
Bioavailability 8-10x ascorbic (Davis 2016). Bypass saturable SVCT1. No osmotic diarrhea at high doses. Form used in canon RCTs (Mason 2023).
Disadvantages
Expensive (~30-50 €/month at 1 g/d). Soapy taste (phospholipids) if liquid. Verify real liposomal vs dry spray marketing.
Pure ascorbic acid · powder or tablets
Best for
Ideal use: 200-500 mg/d maintenance, budget, no pharmacological need.
Advantages
Economical (~5-10 €/month). Historic common cold evidence (Hemilä). Effective for baseline 200-500 mg/d doses.
Disadvantages
SVCT1 saturation at 200 mg · doses >1 g/d lose efficiency + osmotic diarrhea. Gastric acidity some sensitive subjects.
Calcium-buffered · neutral pH
Best for
Ideal use (limited): subjects with gastric intolerance to classic ascorbic.
Advantages
Better gastric tolerance · useful for gastritis or reflux subjects. Provides some Ca.
Disadvantages
Bioavailability without demonstrated real advantage vs standard ascorbic acid (Anderson 2006). "24h" marketing claim without robust evidence.
Ideal use: pro wellness protocol, doses >1 g/d without diarrhea, immune prophylaxis, endothelium.
Ideal use: 200-500 mg/d maintenance, budget, no pharmacological need.
Ideal use (limited): subjects with gastric intolerance to classic ascorbic.
3 forms with radically different bioavailability · canon 2026 pro liposomal · common ascorbic for low dose · Ester-C more marketing than science.