How to choose medications and supplements that actually work

Most decisions about medications and supplements fail not from lack of information, but from a poorly defined problem statement. Peter Attia, in his latest Q&A session, addresses the gap between scientific evidence and real clinical practice: how patients can critically evaluate which interventions make sense to incorporate into a longevity regimen. The approach isn't accumulating more capsules, but establishing clear metrics before starting—biomarkers, observable symptoms, functional changes—that allow you to detect whether a treatment is generating a real effect or merely statistical placebo. For the biohacker or clinician reader, this means completely rethinking your protocol architecture: first the well-formulated question, then rigorous measurement, finally informed decision-making.