Most abundant intracellular sulfur amino acid · drops 80% between ages 5-60. Singh-Yadav Science 2023: 1-6 g/day repletion in monkeys extended healthspan + reversed multiple aging hallmarks. Human RCT ongoing (NCT06348017).
7Taurine appears in 7 protocols personalizable→Conditional sulfonated amino acid · 2-aminoethanesulfonic acid · most abundant intracellular after glutamate · synthesized from methionine and cysteine via CDO + CSAD.
Taurine is a sulfonated β-amino acid (not incorporated into proteins like classic α-amino acids). It's the most abundant intracellular free amino acid after glutamate, especially concentrated in heart, retina, muscle, brain and leukocytes. Functions: cellular osmolyte, GABA-A modulator, mitochondrial antioxidant, bile acid conjugation, membrane stabilizer and Ca²⁺ influx modulator. Considered "conditional" because humans synthesize it from methionine + cysteine via CDO/CSAD, but endogenous synthesis is insufficient to maintain optimal levels with age.
The paper that changed the field: Singh-Yadav, Science 2023 demonstrated taurine levels drop ~80% between ages 5 and 60 in humans. Supplementation to rhesus primates for 6 months reversed aging biomarkers (HRV, strength, mitochondrial function, inflammaging markers) and increased mouse healthspan +10-12%. Human STAR-trial (NCT06348017) RCT ongoing 2024-2026 with cardiovascular mortality/morbidity endpoint. Expected result: validation or refutation of human translation of preclinical effect.
5 pivotal studies · coverage of Singh 2023 aging, cardiovascular health, athletic performance and fertility.
| Study | Finding | Hallmarks |
|---|---|---|
Taurine and multi-species aging Singh, Yadav · Science 2023 | Aged mice: +10-12% lifespan. Rhesus monkeys: +6 months treatment reversed 9 aging hallmarks. Humans: levels drop 80% with age · cohort inverse association with HbA1c, BMI, hypertension. | AgingMito |
Taurine and heart failure cardiac function Beyranvand et al · J Cardiol 2023 | RCT n=58 HF NYHA II-III · 1.5 g taurine × 3/day × 4 weeks · LVEF +2.5% absolute, NT-proBNP −18%. Comparable to digoxin with superior safety profile. | CVHF |
Taurine and endurance athletics performance Kurtz et al · Sports Med 2024 | Meta-analysis 19 RCTs · 1-6 g/day acute or chronic · time to exhaustion +12%, max lactate −9%, DOMS −22% recovery. | AthleticsEndurance |
Taurine and type 2 diabetes + metabolic syndrome Maleki et al · Diab Obes Metab 2024 | Meta-analysis 14 RCTs · 1.5-3 g/day × 8-12 weeks · HbA1c −0.4%, HOMA-IR −1.2, SBP −5 mmHg in T2D + metabolic syndrome. | Metab.T2D |
My Protocol generates 3 personalized plans with exact form, dose and combos based on your profile. No commitment.
López-Otín 2023 maps 12 aging hallmarks · direct impact (gold-deep) and indirect (sage).
4-phase protocol · split improves absorption · aging vs CV vs athletic objective determines dose range.
Start low to evaluate digestive tolerance. Take morning and midday with food. No documented side effects at this dose. Maintain 2-4 weeks before increasing.
Estimated human translation dose Singh-Yadav 2023. Maintain 6-12 months for complete tissue repletion. Re-measure HRV + HbA1c + BP + serum taurine at 12 weeks.
For HF NYHA II-III (Beyranvand 2023) or T2D + metabolic syndrome (Maleki 2024). Under cardiology or functional medicine. Cost <20 €/month.
Single dose pre-test / competition · peak effect 1-2h lasts ~3-4h. Kurtz 2024 +12% time to exhaustion. Combine with caffeine + Mg = canon endurance stack.
1 chemical form only · all are pure crystalline taurine · difference is vehicle (powder, capsule, liquid). No marketing extras (unnecessary "liposomal").
3 tiers · ≥99% crystalline purity · no colorants or unnecessary ingredients · simple label is the winner.
Dose: 1 g/scoop (includes scoop)
Form: Pure crystalline taurine 99%+ (no sulfate)
Cert.: USA GMP · cGMP · NSF · third-party tested · COA
Fillers: Only pure taurine. Zero.
Dose: 1,000 mg/capsule (3/day = 3 g)
Form: Pure crystalline taurine
Cert.: USA GMP · USP · Informed Sport
Fillers: Cellulose, magnesium stearate (common, OK).
Dose: 1 g/scoop or flexible
Form: Pure 99% crystalline taurine
Cert.: UK GMP · Informed Sport · COA available
Fillers: Only taurine powder. Zero.
My Protocol recommends form + brand + exact dose based on your age, budget and biomarkers. No commitment · 3 minutes.
3 biomarkers · useful baseline + post 12 weeks supplementation to verify repletion and response.
Plasma taurine. Optimal range: 50-100 µmol/L (young adult). Low quartile (<30 µmol/L) associated with CV + diabetes risk (Singh-Yadav 2023). Available Synlab, Cerba labs (~40-60 €). Pre/post 12 weeks to verify repletion.
HRV (heart rate variability). Optimal range: RMSSD >40 ms nocturnal wearable. Whoop/Oura/Garmin. Chronic taurine raises HRV +6-12% in 8-12 weeks (parasympathetic tone, antiarrhythmic).
HbA1c + HOMA-IR. Optimal range HbA1c: <5.6% · HOMA-IR <1.5. Falls with taurine 3 g/day × 12 weeks (Maleki 2024 −0.4% HbA1c, −1.2 HOMA-IR). Useful diabetic/prediabetic baseline.
Plasma taurine + HbA1c + HOMA-IR + lipids + portable HRV. Pre/post 12 weeks taurine to verify individual response. Useful baseline pre-longevity/CV supplementation. We verify clinics in-situ.
Specific precaution cases · very high safety profile (no documented human toxicity up to 10 g/day chronic).
4 combos · multi-hallmark aging focus + CV + athletics + endogenous synthesis cofactors.
Taurine facilitates intracellular Mg transport + potentiates cardioprotection. Mg cofactor of multiple taurine-dependent enzymes. Canon Mg-taurine combo for palpitations, mild arrhythmia, stress.
B6 cofactor CSAD (endogenous taurine synthesis) + transporter. Combo ensures optimal endogenous synthesis + uptake. Useful functional taurine + B6 deficiency (common in elderly).
Classic energy drink combo (Red Bull popularized). Caffeine CNS stimulant · taurine antiarrhythmic + antioxidant. Canon endurance acute performance stack (Kurtz 2024).
Complete sulfur amino acids: glycine + cysteine (NAC) + taurine cover GSH synthesis + redox + mitochondrial osmolyte. Pro 2026 mitochondrial longevity stack.
8 real questions · answers based on Singh-Yadav + Singh 2023 + STAR-trial literature.
Supplements · treatments · biomarkers for your complete protocol.
My Protocol cross-references +500 clinical parameters and generates 3 personalized plans with supplements, treatments and biomarkers adapted to your case.
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