Plasmapheresis in Spain: Prices, Indications & Specialised Clinics
Plasma purification to rejuvenate the cellular environment
Table of contents
What is Plasmapheresis?
Definition and how it works
Plasmapheresis is a procedure in which the patient's blood is drawn, the plasma is separated from the blood cells via centrifugation and filtration, and the cells are reinfused with fresh plasma (albumin or young donor plasma). In the longevity context, it is used to remove pro-inflammatory factors that accumulate with ageing (TGF-β1, β2-microglobulin, VCAM-1) — termed 'rejuvenation-inhibiting factors' by researcher Irina Conboy.
Origin and history
Medical plasmapheresis was developed in the 1960s to treat autoimmune diseases. Its application in longevity stems directly from Conboy's parabiosis studies and the research of startup Alkahest (acquired by Grifols) from 2014 onwards.
Benefits of Plasmapheresis
Removal of inflammatory and pro-ageing factors from plasma
Systemic rejuvenation of the cellular environment
Animal model evidence of cognitive improvement and muscle regeneration
Treatment of severe autoimmune diseases
Reduction of autoantibodies and immune complexes
Potential improvement in neurodegeneration
Plasmapheresis protocol step by step
Haematological assessment
Coagulation, calcium, renal and cardiac function. Extended informed consent.
Vascular access
Central or large-bore peripheral venous access. Citrate anticoagulation.
Plasma separation
Continuous centrifugation in a cell separator. Selective plasma extraction (1–1.5 plasma volumes).
Albumin replacement
Reinfusion of cells with 5% human albumin or physiological saline. 2–4 hours total.
Post-procedure monitoring
Calcium, blood pressure and symptom monitoring for 1–2 hours post-procedure. Same-day discharge if uneventful.
Reference equipment for Plasmapheresis
| Equipment | Brand / Model |
|---|---|
| Therapeutic cell separator | Fresenius Kabi COM.TEC / Haemonetics MCS+ |
| Human albumin for replacement | Grifols Albutein / CSL Behring Albuminar |
Clinics on LongevityMap declare their exact equipment for objective scoring.
The science behind Plasmapheresis
Scientific evidence summary
The Irina and Michael Conboy group (UC Berkeley) published in Nature (2005) that parabiosis (circulatory union of young and old mice) rejuvenated the old mouse's tissues. In 2022, they demonstrated that plasmapheresis (dilution of aged plasma) produced equivalent rejuvenation effects without needing young plasma. Clinical studies in Alzheimer's (AMBAR trial, Grifols) show slowed progression with periodic plasmapheresis.
Key published studies
Neutral blood exchange rejuvenates aged mouse tissues
Nature Aging · 2022
Dilution of aged plasma reproduces rejuvenation effects without young plasma.
AMBAR trial: plasmapheresis slows Alzheimer progression
Alzheimer's & Dementia · 2020
Periodic plasmapheresis with albumin slows progression of moderate Alzheimer's by 61%.
How much does Plasmapheresis cost in Spain?
Price per session
€800–2,500 per session
4–8 sessions in initial protocol; six-monthly maintenance
Prices vary by clinic, equipment and practitioner experience. LongevityMap compares price and quality so you always make the best decision.
How we calculate pricesWho is Plasmapheresis for?
Recommended profiles
- 1People over 50 interested in advanced anti-ageing
- 2Patients with severe refractory autoimmune diseases
- 3People with early Alzheimer's or high genetic risk (APOE4)
- 4Advanced biohackers with access to supervised experimental protocols
Precautions and contraindications for Plasmapheresis
Main contraindications
- Severe hypotension or haemodynamic instability
- Severe coagulopathy
- Decompensated heart failure
- Uncorrected hypocalcaemia (citrate anticoagulant chelates calcium)
Treatments that combine with Plasmapheresis
Plasmapheresis shows scientific synergy with these treatments:
Where to get Plasmapheresis in Spain?
Compare Plasmapheresis clinics across Spain's main cities. Each page includes local prices, quality scores and verified rankings.
Frequently asked questions about Plasmapheresis
Is longevity plasmapheresis different from medical plasmapheresis?▾
Is there solid clinical evidence in healthy humans?▾
How long does a session last?▾
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Generate My Protocol for freeContent created by the LongevityMap editorial team based on peer-reviewed scientific literature. Sources: PubMed, Cochrane Library. This content does not replace professional medical advice. Our team · Methodology