Plasmapheresis in Spain: Prices, Indications & Specialised Clinics

Plasmapheresis is a procedure in which the patient's blood is drawn, the plasma is separated from the blood cells via centrifugation and filtration, and the cells are reinfused with fresh plasma (albumin or young donor plasma). In the longevity context, it is used to remove pro-inflammatory factors that accumulate with ageing (TGF-β1, β2-microglobulin, VCAM-1) — termed 'rejuvenation-inhibiting factors' by researcher Irina Conboy.

Origin and history

Medical plasmapheresis was developed in the 1960s to treat autoimmune diseases. Its application in longevity stems directly from Conboy's parabiosis studies and the research of startup Alkahest (acquired by Grifols) from 2014 onwards.

1. Haematological assessment Coagulation, calcium, renal and cardiac function. Extended informed consent.

2. Vascular access Central or large-bore peripheral venous access. Citrate anticoagulation.

3. Plasma separation Continuous centrifugation in a cell separator. Selective plasma extraction (1–1.5 plasma volumes).

4. Albumin replacement Reinfusion of cells with 5% human albumin or physiological saline. 2–4 hours total.

5. Post-procedure monitoring Calcium, blood pressure and symptom monitoring for 1–2 hours post-procedure. Same-day discharge if uneventful.

• Removal of inflammatory and pro-ageing factors from plasma
• Systemic rejuvenation of the cellular environment
• Animal model evidence of cognitive improvement and muscle regeneration
• Treatment of severe autoimmune diseases
• Reduction of autoantibodies and immune complexes
• Potential improvement in neurodegeneration

• 1People over 50 interested in advanced anti-ageing
• 2Patients with severe refractory autoimmune diseases
• 3People with early Alzheimer's or high genetic risk (APOE4)
• 4Advanced biohackers with access to supervised experimental protocols

• Severe hypotension or haemodynamic instability
• Severe coagulopathy
• Decompensated heart failure
• Uncorrected hypocalcaemia (citrate anticoagulant chelates calcium)

Clinics on LongevityMap declare their exact equipment for objective scoring.

€800–2,500 per session

4–8 sessions in initial protocol; six-monthly maintenance

Prices vary by clinic, equipment and practitioner experience. LongevityMap compares price and quality so you always make the best decision.

The Irina and Michael Conboy group (UC Berkeley) published in Nature (2005) that parabiosis (circulatory union of young and old mice) rejuvenated the old mouse's tissues. In 2022, they demonstrated that plasmapheresis (dilution of aged plasma) produced equivalent rejuvenation effects without needing young plasma. Clinical studies in Alzheimer's (AMBAR trial, Grifols) show slowed progression with periodic plasmapheresis.