3 forms · bioavailability is everything · pure crystalline is marketing if you want real senolytic doses · liposomal or lipid carrier is mandatory.
Quicksilver, Renue By Science
Best for
Ideal use: canon senolytic protocol · monthly pulses · pro-longevity budget.
Advantages
Oral bioavailability ~25-30% (vs ~1% crystalline). Senolytic plasma concentration achievable with 1,000-1,500 mg/pulse. Form used in Mayo 2024 trials (Verdoorn COVID).
Disadvantages
Expensive (~35-60 €/pulse · 100 €/month). Phospholipid vehicle requires refrigeration after opening.
Liposoluble nano-emulsion
Best for
Ideal use: alternative to liposomal with better logistics (no refrigeration). Monthly pulse.
Advantages
Bioavailability ~15-20x crystalline · oral capsule without refrigeration. Cost between liposomal and crystalline.
Disadvantages
Patented brand · less available in Spain (import). Limited head-to-head studies with liposomal.
DoNotAge, Double Wood standard
Best for
Ideal use (limited): chronic flavonoid-stack supplement, NOT for senolytic pulse protocol.
Advantages
Economical (~15-25 €/pulse). Good for concentrated fisetin + dietary flavonoid synergies.
Disadvantages
Oral bioavailability ~1-2% · unlikely to reach senolytic plasma concentrations (~1-10 µM) except impractical doses >5 g/day. Use only in diet supplement or flavonoid stack.
Ideal use: canon senolytic protocol · monthly pulses · pro-longevity budget.
Ideal use: alternative to liposomal with better logistics (no refrigeration). Monthly pulse.
Ideal use (limited): chronic flavonoid-stack supplement, NOT for senolytic pulse protocol.
3 forms · bioavailability is everything · pure crystalline is marketing if you want real senolytic doses · liposomal or lipid carrier is mandatory.