Apo-LF (Fe-unsaturated) canon for anemia + antimicrobial · Liposomal boost oral bioavailability · Holo-LF specific niche.
<5% Fe · canon RCT form
Best for
Ideal use: anemia repletion · antimicrobial · antiviral · canon default.
Advantages
Form used in Paesano 2024 + Campione + most RCTs. Free Fe-binding capacity in gut (repletion) + antimicrobial (deprives pathogens). Stable at acidic pH.
Disadvantages
Expensive vs ferrous sulfate. Production requires EDTA desaturation + dialysis process.
Phosphatidylcholine-encapsulated · absorption boost
Best for
Ideal use: longevity protocol · cardio · maximize absorption at lower dose.
Advantages
Improved oral bioavailability 2-3× vs standard apo-LF. Useful at lower effective doses. Some cardio/longevity studies use liposomal.
Disadvantages
Expensive (~€50-70/month). Few head-to-head studies vs standard apo.
≈100% Fe-saturated
Best for
Ideal use: specific niche · NOT first-line. Apo-LF preferred as default.
Advantages
Higher direct Fe input (≈1.5 mg Fe/100 mg LF). Useful in severe Fe depletion cases when apo doesn't respond.
Disadvantages
Lacks free intestinal Fe-binding capacity (main mechanism). NOT recommended first-line for anemia.
Ideal use: anemia repletion · antimicrobial · antiviral · canon default.
Ideal use: longevity protocol · cardio · maximize absorption at lower dose.
Ideal use: specific niche · NOT first-line. Apo-LF preferred as default.
Apo-LF (Fe-unsaturated) canon for anemia + antimicrobial · Liposomal boost oral bioavailability · Holo-LF specific niche.