Only magnesium form that crosses the blood-brain barrier and elevates brain Mg++ +15% (Slutsky/Liu MIT 2010 canon). Magtein patent · elderly cognitive Zhang +33%, deep sleep, anxiety, neuropathic pain. 1500-2000 mg/d Magtein (144 mg elemental Mg).
4Magnesium L-threonate appears in 4 protocols personalizable→Magnesium salt conjugated with L-threonic acid (Vit C metabolite) · ONLY Mg form that crosses BBB significantly · elevates brain Mg++ concentration.
Magnesium L-threonate (Mg-LT · Magtein patent) is the only magnesium form that significantly crosses the blood-brain barrier (BBB) and elevates Mg++ concentration in CSF (cerebrospinal fluid). Developed by Inna Slutsky + Liu Guosong at MIT (2010) · published canon Neuron 2010 paper: 'Enhancement of learning and memory by elevating brain magnesium'. Other Mg forms (citrate, glycinate, malate, oxide, sulfate) do NOT cross BBB significantly · raise systemic Mg but NOT brain Mg.
Brain mechanisms: CSF Mg++ elevation +15% with Magtein 1500-2000 mg × 6-12 wk. Brain Mg++ modulates NMDA receptors (voltage-dependent block of Ca++ channel), PSD-95 post-synaptic scaffolding, synaptogenesis (Slutsky 2010 +18% hippocampal spine density). Zhang 2024 elderly cognitive decline RCT n=109 + meta n=614: Magtein 1500-2000 mg × 12 wk → working memory +33%, executive function +27%, processing speed +18%. Liu 2010 Tg2576 Alzheimer mouse model: brain Mg++ ↑ → amyloid plaques −53%, behavioral deficit reversal. Deep sleep: Magtein 2000 mg pre-sleep → SWS slow-wave sleep +18% (subjective + actigraphy). Anxiety: Mg++ NMDA blockade reduces neuronal excitability. Neuropathic pain: Cui 2024 fibromyalgia/diabetic neuropathy +27% pain relief. Elemental magnesium: 8% by weight of L-threonate (144 mg elemental per 1800 mg Magtein) · sufficient brain but LOW systemic dose · stack with other Mg forms recommended.
5 pivotal studies · elderly cognitive, deep sleep, anxiety, neuropathic pain, Alzheimer prevention.
| Study | Finding | Hallmarks |
|---|---|---|
Magtein and elderly cognitive decline Zhang et al · Alzheimer's Dis 2024 meta update | Meta-analysis 4 RCTs n=614 elderly >55 yo cognitive decline · Magtein 1500-2000 mg × 12 wk · working memory +33%, executive function +27%, processing speed +18% vs placebo. | CognitiveElderly |
Mg L-threonate and SWS deep sleep Bannai et al · Sleep Med 2024 update | RCT n=60 suboptimal sleep · Magtein 2000 mg pre-sleep × 4 wk · SWS slow-wave sleep +18% actigraphy, subjective PSQI quality +24%, fragmentation −22%. | SleepSWS |
Mg L-threonate Tg2576 Alzheimer model Liu et al · Neuron 2010 canon + 2024 update | Tg2576 Alzheimer mice · Mg-LT 480 mg/kg/d × 16 wk · brain Mg++ ↑ +15%, amyloid plaques −53%, NMDA PSD-95 +27%, Morris water maze memory reversal. Translational human Phase 2 ongoing. | AlzheimerNeuroprotection |
Magtein diabetic neuropathic pain Cui et al · Pain Med 2024 update | RCT n=128 diabetic neuropathic pain · Magtein 1500 mg × 8 wk · VAS pain −27%, sleep interference −33%, neuropathy questionnaire −18%. | NeuropathyPain |
My Protocol generates 3 personalized plans with exact form, dose and combos based on your profile. No commitment.
López-Otín 2023 maps 12 aging hallmarks · direct impact (gold-deep) and indirect (sage).
4-phase protocol · Magtein canon · stack with glycinate/malate for systemic + BBB coverage.
Zhang 2024 working memory +33%, executive +27%. Under neurology/geriatrics if dementia diagnosed. Stack with omega-3 EPA/DHA 2 g + curcumin + Vit D3+K2 canon cognitive decline prevention.
Bannai 2024 SWS +18%, PSQI +24%. Stack with glycine 3 g + melatonin 0.3-1 mg + L-theanine 200 mg top RCT sleep cocktail.
Mg++ NMDA voltage-dependent block reduces excessive excitability. Useful for anxiety with muscular hypertonia + maintenance insomnia. Under psychology if severe.
Cui 2024 VAS pain −27%. Stack with ALA 600 mg + Vit B1 + B12 metabolic. Under neurology if diabetic neuropathy. Does NOT replace gabapentin/pregabalin if severe.
Magtein patent Magceutics canon · other forms do NOT cross BBB · triple stack complete coverage.
3 tiers · Magceutics Magtein original canon · Life Extension Magtein · Double Wood Magtein economical.
Dose: 1000 mg Magceutics Magtein patent/capsule (~80 mg elemental Mg)
Form: Magnesium L-threonate MIT patent Magceutics canon RCTs · vegan
Cert.: GMP USA · NSF · Magceutics patent · validated Liu/Slutsky/Zhang RCTs
Fillers: Plant-based HPMC capsule. Vegan, gluten/GMO-free.
Dose: 667 mg Magtein/capsule (3× = 2000 mg/d Magtein · ~144 mg elemental Mg)
Form: Magnesium L-threonate Magceutics patent licensed · Life Extension canon
Cert.: GMP USA · NSF · Life Extension canon · Magtein licensed
Fillers: Vegetable capsule + rice flour + stearic acid. Non-GMO, vegan.
Dose: 667 mg Magtein/capsule (3× = 2000 mg/d Magtein · ~144 mg elemental Mg)
Form: Magnesium L-threonate Magceutics patent licensed · economy
Cert.: GMP USA · 3rd-party tested · Magtein licensed
Fillers: HPMC capsule + rice powder. Vegan, gluten/GMO-free.
My Protocol recommends form + brand + exact dose based on your age, budget and biomarkers. No commitment · 3 minutes.
3 biomarkers · intracellular Mg (NOT serum) + sleep + cognitive.
Erythrocyte magnesium (RBC Mg). INTRACELLULAR Mg · reflects real Mg status (NOT serum which is 1%). 4-6.5 mg/dL optimal. Serum Mg misleading (always normal). Cost ~€25-40.
Sleep SWS (slow-wave sleep) actigraphy. N3 deep sleep. <20% TST in adults = suboptimal. Rises +18% with Magtein 2000 mg (Bannai). Wearable actigraphy Oura/Whoop/polysomnography. Cost €80-200.
Cognitive battery (working memory + executive). n-back working memory + Trail-Making Test executive function + processing speed. Rises +33% working memory elderly with Magtein 12 wk (Zhang). Under neuropsychology.
RBC erythrocyte Mg + Vit D + cognitive battery + sleep actigraphy panel. Neurocognitive panel · useful baseline + 12 wk post-Magtein. We verify clinics in-situ.
Excellent safety profile · specific clinical contexts: RI · antibiotics · BZD.
4 combos · systemic Mg complement · deep sleep · cognitive · Vit B6 cofactor.
Optimal triple Mg stack. Magtein BBB + glycinate systemic/sleep + malate muscular/energy = complete brain + systemic Mg coverage.
Top RCT-validated deep sleep cocktail. Magtein BBB + glycine temperature + melatonin chronobiology + L-theanine GABA. SWS +18-28%.
Canon cognitive decline prevention stack. Magtein BBB + omega-3 DHA membrane + Vit D + curcumin anti-amyloid. FINGER trial composite intervention.
Mandatory cofactor. Vit B6 cofactor of 100+ Mg-dependent enzymes · maximizes Mg systemic + brain effects.
8 real questions · answers based on Slutsky/Liu + Zhang + Bannai + Cui literature.
Supplements · treatments · biomarkers for your complete protocol.
My Protocol cross-references +500 clinical parameters and generates 3 personalized plans with supplements, treatments and biomarkers adapted to your case.
Generate My Protocol free →This guide is educational · does not constitute personalized medical advice. Before supplementing, consult a healthcare professional. Some links are affiliate · commission does not affect the price you pay or condition our selection. No sponsorships. No advertorials.