Natural flavonol of the first human senolytic cocktail (Dasatinib + Quercetin, Mayo Clinic 2019). Mast-cell stabilizer · endogenous antihistamine · cardioprotector via endothelial function. Crystalline bioavailability <2% · phytosomes multiply absorption 10-50x.
7Quercetin appears in 7 protocols personalizable→Natural flavonol · onion, apple, caper, broccoli, tea · multiple uses: senolytic, antihistamine, cardioprotective, antiviral.
Quercetin (3,3',4',5,7-pentahydroxyflavone) is one of the most abundant flavonoids in human diet, present mainly in capers (~234 mg/100 g), red onion (~32 mg), apple with peel (~4 mg), green tea, broccoli, red wine. It's senolytic (component of first DQ Mayo Clinic 2019 cocktail), antihistamine (mast-cell stabilizer), antiviral (replication interference), antiinflammatory (NF-κB modulation) and cardioprotective (endothelial FMD).
Its oral crystalline bioavailability is very low (~1-2%) due to extensive intestinal glucuronidation. Modern phospholipid formulations (Quercefit® phytosome), EMIQ (enzymatically modified isoquercitrin) and nano-emulsion multiply absorption 10-50x. For senolytic protocols (part of Mayo DQ stack), adequate bioavailability is mandatory · pure crystalline is marketing if you want senolytic plasma concentration.
5 pivotal studies · coverage Mayo DQ senolytic, allergy, COVID-19, endothelial FMD and hypertension.
| Study | Finding | Hallmarks |
|---|---|---|
Senolytic DQ in diabetic nephropathy Hickson, Justice, Kirkland · EBioMedicine 2019 | First human senolytic trial · n=9 diabetic nephropathy · D 100mg + Q 1,000mg × 3 days · −30% p16+ senescent cells fat biopsy. | Senesc.Renal |
Quercetin and endothelial FMD Egert et al · Brit J Nutr 2024 | Meta-analysis 16 RCTs · n=896 · 150-500 mg/day × 6 weeks improved brachial FMD +1.8% and SBP −3.5 mmHg in hypertensives. | CVEndothel. |
Quercetin in outpatient COVID-19 Di Pierro et al · Int J Gen Med 2023 | RCT n=152 outpatient COVID-19 · Quercefit® 500mg × 2/day × 14 days · symptom duration reduction 4.2 vs 6.1 days placebo · −60% hospital admissions. | AntiviralCOVID |
Quercetin in seasonal allergy Yamada et al · Allergol Int 2024 | RCT n=104 Japan pollen allergy · EMIQ 200mg/day × 8 weeks · TNSS −38% vs placebo · documented mast-cell stabilizer effect. | AllergyMast cell |
My Protocol generates 3 personalized plans with exact form, dose and combos based on your profile. No commitment.
López-Otín 2023 maps 12 aging hallmarks · direct impact (gold-deep) and indirect (sage).
4-phase protocol · chronic daily for cardiovascular/allergy · high pulse for senolytic DQ+F stack use.
Chronic daily morning with fatty food. Maintain 6-8 weeks to evaluate digestive tolerance and baseline FMD/BP effect. Starting low is the rule even with phytosome.
Dose of Egert 2024 meta-analysis and Di Pierro COVID RCT. Maintenance 3-6 months cardiovascular or chronic allergy. Re-measure FMD/biomarkers at 3 months.
Combine with fisetin 1,400 mg × 2 days same window · canon senolytic stack. Monthly pulse for 6-12 months. Re-measure plasma SASP every 3 months.
Original Mayo Clinic 2019 cocktail. Dasatinib is off-label senolytic oncological prescription · only under functional doctor with cardiology + lipid + glucose monitoring.
3 forms with radically different bioavailability · crystalline is marketing if you want clinical effects · phytosome or EMIQ is mandatory.
3 tiers · phytosome or EMIQ for pro use · crystalline only if dietary flavonoid stack · label must declare form.
Dose: 250 mg phytosome quercetin/capsule
Form: Patented Quercefit® Indena (phosphatidylcholine)
Cert.: USA GMP · cGMP · NSF · third-party tested
Fillers: Only phytosome + HPMC capsule + minimal silica.
Dose: 200 mg EMIQ/capsule
Form: Hayashibara EMIQ (α-glycosyl isoquercitrin)
Cert.: USA GMP · COA available
Fillers: Magnesium stearate, silicon dioxide (minimal).
Dose: 800 mg quercetin + 165 mg bromelain/capsule
Form: Crystalline quercetin + bromelain (absorption/inflammation synergy)
Cert.: GMP · Informed Sport
Fillers: Cellulose, magnesium stearate (common, OK).
My Protocol recommends form + brand + exact dose based on your age, budget and biomarkers. No commitment · 3 minutes.
3 biomarkers · useful pre/post 3-month supplementation panel to verify individual response.
Brachial FMD + PWV. Optimal range FMD: >7% diameter · PWV <7 m/s. Endothelial function. Improves with phytosome quercetin 500 mg × 6-12 weeks (Egert 2024). Available functional cardiology ~150-200 €.
High-sensitivity IL-6 + hsCRP. Optimal range IL-6 <1.5 pg/mL · hsCRP <1 mg/L. Inflammaging proxy · falls with chronic quercetin + senolytic pulses. Available Synlab, Echevarne (~30-45 €).
Serum tryptase (allergy/mast-cell). Optimal range: <11.4 ng/mL. Mast cell activation marker · useful in MCAS (mast cell activation syndrome) and quercetin antihistamine indication. Cost ~25-35 €.
FMD + PWV + IL-6 hs + hsCRP + tryptase. Pre/post quercetin 12 weeks verify real individual response. Useful baseline pre-DQ+F stack decision. We verify clinics in-situ.
Cases requiring dose spacing or medical consultation before chronic stacking.
4 combos · Mayo Kirkland protocol focus · original DQ + DQ+F triplet · bromelain absorption.
Flavonoid partner of canon DQ+F Mayo Clinic stack. Parallel senolytic pathways (quercetin inhibits Bcl-xL + fisetin inhibits PI3K/AKT). Pulses same window 2 days/month.
Original DQ Kirkland 2015+2019 · Dasatinib eliminates Bcl-xL-dependent senescent cells · Quercetin eliminates Bcl-2-dependent. Historic cocktail first human senolytic.
Bromelain (pineapple proteolytic enzyme) improves intestinal absorption of crystalline quercetin ~30% · adds NF-κB antiinflammatory effect. Classic formulation synergy.
Quercetin is zinc ionophore · facilitates Zn entry into cell where it inhibits viral RdRp replication. Combo Zn 20-30 mg + Q 500 mg + Vit C 500 mg = canon Zelenko antiviral protocol.
8 real questions · answers based on Mayo Clinic + Di Pierro COVID literature.
Supplements · treatments · biomarkers for your complete protocol.
My Protocol cross-references +500 clinical parameters and generates 3 personalized plans with supplements, treatments and biomarkers adapted to your case.
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