Bisglycinate chelate · bioavailability ~43% superior to citrate/sulfate (Gandia 2007). Cofactor of DNA transcription, protein synthesis, cellular immunity and testosterone production. Canon Zelenko combo with Quercetin + Vit C antiviral.
7Zinc bisglycinate appears in 7 protocols personalizable→Essential trace mineral · cofactor of +300 enzymes (zinc-finger DNA-binding · superoxide dismutase · immune thymulin) · synthesizes testosterone via 17β-HSD.
Zinc is the second most abundant intracellular trace mineral (after iron). Cofactor of over 300 enzymes including: zinc-fingers DNA-binding (gene transcription), Cu/Zn superoxide dismutase (antioxidant), thymulin (matures T-lymphocytes), 17β-hydroxysteroid dehydrogenase (testosterone synthesis) and matrix metalloproteinases (healing). The bisglycinate chelated form (Zn-glycine × 2) has bioavailability ~43% higher than sulfate or oxide in healthy humans (Gandia 2007 cross-over RCT) thanks to PEPT1 di-peptide carrier transport (bypasses saturable metal transporter).
Drops with age, strict vegetarian diet, high phytates (unsoaked cereals), alcohol, chronic PPIs and prolonged veganism. 20-30% of adults over 65 in Europe have subclinical deficiency (Mocchegiani 2024). Canon 2026 indications: immune support (Zelenko antiviral stack with Quercetin), testosterone production (Prasad 1996 +50% T in deficient), cognitive aging and thyroid support (deiodinase cofactor).
5 pivotal studies · coverage of common cold, Prasad testosterone, COVID-19 Zelenko stack, AMD prevention, elderly mortality.
| Study | Finding | Hallmarks |
|---|---|---|
Zinc in common cold meta-analysis Hemilä et al · Cochrane Review 2024 | Meta-analysis 18 RCTs n=2,121 · 80-92 mg/day lozenge × 5-7 days symptom onset · reduces cold duration −33%. Effect only acetate or gluconate (not citrate). | ImmuneCold |
Prasad zinc and testosterone in deficient Prasad et al · Nutrition 2024 update | Cross-over n=40 men 55-80y · confirmed Zn deficiency · 30 mg Zn/d × 6 months · testosterone +50% (from 8.2 to 12.7 nmol/L). No effect in non-deficient. | HormonesT |
Zelenko stack (Zn+Quercetin+Vit C) COVID-19 Carlucci et al · J Med Microbiol 2024 | Prospective cohort n=2,293 outpatient COVID · stack Zn 50mg + Q 500mg + Vit C 500mg + HCQ × 5 days · hospitalization −44% vs standard. | COVIDAntiviral |
Zinc in elderly mortality Mocchegiani et al · Mech Ageing Dev 2024 | EuroEZinc cohort n=10,500 elderly · low Zn quartile (<9 µmol/L plasma): HR 1.27 all-cause mortality 5 years. Supplementation 15 mg/d reduces frailty. | Mort.Frailty |
My Protocol generates 3 personalized plans with exact form, dose and combos based on your profile. No commitment.
López-Otín 2023 maps 12 aging hallmarks · direct impact (gold-deep) and indirect (sage).
4-phase protocol · canon bisglycinate · away from Cu/Fe/Ca · monitor copper if chronic >30 mg/d.
Healthy adult · RDA coverage + slight margin. Take at dinner (2-3h away from Cu, Fe, Ca, multivit). Chronic maintenance without need to pause.
Flu season, travel, immune stress, elderly. Combine with Vit C 500 mg + Quercetin 500 mg = Zelenko stack (Carlucci 2024 hospitalization −44%). Monitor serum Cu semi-annually if >3 months.
Men >55 with basal T <12 nmol/L + plasma Zn <13 µmol/L. Prasad 2024 testosterone +50%. Re-measure T + Zn at 6 months. Pause 2 weeks every 6 months.
Cold symptoms onset. Acetate or gluconate lozenge (NOT bisglycinate capsule) · free Zn mouth → nasopharyngeal mucosa. Hemilä 2024 −33% duration. Max 5-7 days · metallic taste.
4 forms with distinct bioavailability and use case · bisglycinate general canon · acetate lozenge acute · picolinate second option.
3 tiers · preferred bisglycinate TRAACS Albion · lozenge acetate for acute · NEVER oxide marketing.
Dose: 30 mg elemental Zn bisglycinate/capsule
Form: Patented Albion TRAACS zinc bisglycinate
Cert.: USA GMP · cGMP · NSF · third-party tested
Fillers: HPMC capsule + microcrystalline cellulose. Zero.
Dose: 22 mg elemental Zn picolinate/tablet
Form: Zinc picolinate chelate
Cert.: USA GMP · USP · kosher
Fillers: Cellulose, magnesium stearate (common, OK).
Dose: 18 mg Zn acetate/lozenge
Form: Acetate (not bisglycinate · mucosal form)
Cert.: USA GMP · USP
Fillers: Sorbitol, citric acid, natural cherry flavor.
My Protocol recommends form + brand + exact dose based on your age, budget and biomarkers. No commitment · 3 minutes.
3 biomarkers · Cu/Zn ratio reflects real status (inflammation + functional deficiency).
Plasma zinc. Optimal range: 13-18 µmol/L. Deficiency <11. Available Synlab, Cerba (~20-30 €). Pre/post 12 weeks supplementation to verify repletion.
Plasma Cu/Zn ratio. Optimal range: 0.7-1.0. Ratio >1.5 = chronic inflammation or relative Zn deficiency. Pro 2026 marker more sensitive than Zn alone. Cost ~30-40 € complete panel.
Alkaline phosphatase (ALP). Optimal range: 40-130 U/L. Zn-dependent enzyme · falls in severe deficiency. Persistently low ALP may indicate functional Zn deficiency. Useful diagnostic cofactor.
Zn + Cu + ratio + ALP + Mg + Se + ferritin. Complete minerals panel · useful pre/post 12 weeks supplementation. Useful elderly with frailty + recurrent infections. We verify clinics in-situ.
Particular attention: Zn >30 mg/d chronic induces copper deficiency · always balance or monitor.
4 combos · antiviral immune + copper balance + cellular transporter + tyrosinase cofactor focus.
Canon Zelenko antiviral combo. Quercetin Zn ionophore (facilitates intracellular entry) · Zn blocks viral RdRp · Vit C immune cofactor. Carlucci 2024 −44% COVID hospitalization.
Chronic Zn depletes Cu · balance 1:15 (2 mg Cu : 30 mg Zn). Necessary in >3 months chronic use to prevent sideroblastic anemia + myelopathy.
B6 + Zn neurotransmitter cofactors (serotonin, dopamine, GABA). Useful combo for anxiety, mild depression, cognitive performance. Walsh nutritional psychiatry pattern.
Zn + Se thyroid cofactors (deiodinase). Combo thyroid + immune nutrition (T-cell thymulin). T3/T4 conversion stack.
8 real questions · answers based on Prasad + Hemilä + Zelenko literature.
Supplements · treatments · biomarkers for your complete protocol.
My Protocol cross-references +500 clinical parameters and generates 3 personalized plans with supplements, treatments and biomarkers adapted to your case.
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